Key result
Higher arterial stiffness, measured by brachial-ankle pulse wave velocity, significantly predicted the presence of Alzheimer's disease (OR 6.46), vascular dementia, mixed dementia, and mild cognitive impairment compared to controls.
Why the study?
It remains unclear whether patients with Alzheimer disease, vascular dementia, and mixed dementia exhibit more advanced arterial stiffness compared with community residents without dementia.
Does arterial stiffness correlate with cognitive impairment in elderly outpatients with dementia and mild cognitive impairment compared to community residents without dementia?
Cross-Sectional (n=655)
No
Does arterial stiffness correlate with cognitive impairment in elderly outpatients with dementia and mild cognitive impairment compared to community residents without dementia?
Arterial stiffness may correlate with dementia subtypes but not MCI; hypothesis-generating and requires prospective trials before clinical adoption.
BACKGROUND: It is unclear whether the dementia patients with Alzheimer's disease (AD) and vascular dementia (VaD) and mixed dementia (MIX, including AD and VaD) would have more developed arterial stiffness as compared with local residents without dementia. The aim of this study was to assess arterial stiffness and cognitive function in different types of dementia patients [AD, VaD, MIX and mild cognitive impairment (MCI)] and community residents without dementia. METHODS: This was a single-center, cross-sectional observational study. We studied a cohort of 600 elderly outpatients with a complaint of memory loss, who were divided into four groups (AD, VaD, MIX and MCI). In addition, they were compared with 55 age-matched local residents without dementia (Controls). We assessed arterial stiffness by brachial-ankle pulse wave velocity (baPWV) and the global cognitive function by the Mini-Mental State Examination (MMSE). CONCLUSIONS: The findings suggest that MCI and dementia patients have stiffer arteries as compared with age-matched local residents, although global cognitive function may be comparable between MCI and the local residents.
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Hirasawa et al. (2022) conducted a cross-sectional in Dementia (Alzheimer's disease, Vascular dementia, Mixed dementia) and Mild Cognitive Impairment (n=655). Higher arterial stiffness (baPWV) vs. Lower arterial stiffness was evaluated on Presence of Alzheimer's disease (OR 6.46, 95% CI 2.74-15.25). Higher arterial stiffness, measured by brachial-ankle pulse wave velocity, significantly predicted the presence of Alzheimer's disease (OR 6.46), vascular dementia, mixed dementia, and mild cognitive impairment compared to controls.
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