Temsirolimus, an Inhibitor of Mammalian Target of Rapamycin

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Temsirolimus (Torisel, Wyeth Pharmaceuticals) is an inhibitor of mammalian target of rapamycin (mTOR), a molecule implicated in multiple tumor-promoting intracellular signaling pathways. Temsirolimus recently became the first Food and Drug Administration–approved mTOR-targeted agent based on a