Key result
A 9-month-old male infant with Timothy syndrome (LQT8) experienced severe arrhythmias and cardiac arrest during general anesthesia, highlighting the need for individualized perioperative management.
Population
1 9-month-old male infant with suspected Timothy syndrome and syndactyly of both hands, presenting for…
Design
Case_report
Follow-up
5 months
Authors
Discussion
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Member takes
Implication
May signal high arrhythmia risk in LQT8 infants under anesthesia; hypothesis-generating and should not yet change practice.
Study Design
Type
Case Report (n=1)
Structured PICO
P
Population
A 9-month-old male infant with Timothy syndrome (LQT8) undergoing general anesthesia for epicardial pacemaker placement.
E
Exposure
General anesthesia (thiopentone, fentanyl, pancuronium, sevoflurane/isoflurane, nitrous oxide) with reversal using atropine and neostigmine, and local bupivacaine infiltration.
O
Outcome
Adverse cardiac events during anesthesia (T wave alternans, bradycardia, loss of pacemaker capture, cardiac arrest)safety
Patients with Long QT Syndrome, particularly LQT8 (Timothy syndrome), are at high risk for malignant arrhythmias during general anesthesia and require careful multidisciplinary management.
Cite This Study
Nathan et al. (2012) conducted a case report in Long QT syndrome (Timothy syndrome / LQT8) (n=1). General anesthesia was evaluated. A 9-month-old male infant with Timothy syndrome (LQT8) experienced severe arrhythmias and cardiac arrest during general anesthesia, highlighting the need for individualized perioperative management.