Retrospective cohort study reveals varying cumulative live-birth rates across infertility etiologies in IVF, indicating that specific underlying causes strongly dictate treatment success.
Aims: To evaluate whether the various causes of infertility have an impact on cumulative clinical pregnancy rate (CCPR) and cumulative live-birth rate (CLBR) following first ovum pickup. Settings and Design: A retrospective cohort study between January, 2015 and December, 2018 at the tertiary assisted reproductive technology (ART) Centre in northern India (Jindal IVF and Sant Memorial Hospital, Chandigarh). Materials and Methods: A total of 788 patients who underwent first oocyte retrieval during the study period were included based on selection criteria. All patients were divided into various diagnostic categories. All ovum pickup along with subsequent fresh- and frozen-embryo transfer attempts (maximum three) till: a) attained a clinical pregnancy; b) attained a live birth; or c) all the embryos were transferred. The data were analyzed using SPSS-22. The descriptive and comparative analysis was performed using one-way analysis of variance. Results: The overall CCPR and CLBR were 54.82% and 50.63%, respectively. The live-birth rates were lowest in patients with the diagnosis of poor responders (25%) and those with genital tuberculosis (37.78%) and highest in those patients with endometriosis (64.10%) and male factor infertility (64.71%).
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Kanwatia et al. (2021) studied this question.
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