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May 18, 2018International Journal of Molecular SciencesOpen Access

GDF11 Modulates Ca2+-Dependent Smad2/3 Signaling to Prevent Cardiomyocyte Hypertrophy

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Key result

GDF11 prevented cardiomyocyte hypertrophy induced by testosterone or phenylephrine by modulating Ca2+ signaling and the Smad2/3 pathway.

Why the study?

Does GDF11 prevent cardiomyocyte hypertrophy in neonatal rat cardiomyocytes?

Population

Neonatal rat cardiomyocytes

Comparison

GDF11 pretreatment over 24 h vs Hypertrophic agents alone without GDF11

Design

Preclinical

Follow-up

24 hours

Authors

JDJavier Nebreda DuránClínica DiagonalMTMayarling F. TroncosoAdvanced Center for Chronic DiseasesDLDaniel LagosUniversity of Cambridge

Discussion

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Implication

Hypothesis-generating in neonatal rat cardiomyocytes; leaves open translation to human hypertrophy therapies.

Structured PICO

Does GDF11 prevent cardiomyocyte hypertrophy in neonatal rat cardiomyocytes?

P
Population
Neonatal rat cardiomyocytes
I
Intervention
GDF11 (Growth differentiation factor 11) pretreatment over 24 h
C
Comparator
Hypertrophic agents alone (100 nM testosterone or 50 μM phenylephrine) without GDF11
O
Outcome
Cardiomyocyte size and [3H]-leucine incorporationsurrogate

GDF11 exerts antihypertrophic effects in cardiomyocytes through modulation of IP3-dependent Ca2+ signaling and the Smad2/3 pathway.

Cite This Study

Durán et al. (2018) studied Cardiomyocyte hypertrophy. GDF11 vs. Hypertrophic agents (100 nM testosterone or 50 μM phenylephrine) was evaluated on Cardiomyocyte size and [3H]-leucine incorporation. GDF11 prevented cardiomyocyte hypertrophy induced by testosterone or phenylephrine by modulating Ca2+ signaling and the Smad2/3 pathway.

synapsesocial.com/papers/6a7c64462c076ac3c81031bdhttps://doi.org/10.3390/ijms19051508
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Smad transcription factors2005 · 2,480 citations
  2. 2Caveolae-localized L-type Ca2+ channels do not contribute to function or hypertrophic signalling in the mouse heart2017 · 23 citations
  3. 3TGF-β-induced Ca2+influx involves the type III IP3receptor and regulates actin cytoskeleton2002 · 56 citations
  4. 4Characterization of Human FAST-1, a TGFβ and Activin Signal Transducer1998 · 231 citations
  5. 5Cytoplasmic Signaling Pathways That Regulate Cardiac Hypertrophy2001 · 693 citations