Population
Digitonin-lysed adult rat ventricular cardiomyocytes
Comparison
Simulated ischemia and reperfusion vs Control conditions
Design
Preclinical
Authors
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May impair SR Ca²⁺ handling in ischemic myocytes; leaves open relevance to in vivo reperfusion injury or human disease.
Simulated myocardial ischemia and reperfusion significantly decrease calcium uptake by the sarcoplasmic reticulum in adult rat cardiomyocytes.
Hohl et al. (1992) studied this question.
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