Key result
A personalized lifestyle modification program significantly reduced the 10-year cardiovascular Framingham risk score compared to standard care in women with moderate-to-high risk of cardiovascular disease.
Why the study?
CVD is the major cause of global mortality, and applying a comprehensive interventional program may reduce its incidence and complications.
Does a personalized lifestyle modification program reduce cardiovascular disease risk factors and Framingham risk score in women with moderate-to-high risk of CVD?
RCT (n=59)
Single-blind
Eligible participants randomly chose a card that assigned them to the intervention or control group
No
Does a personalized lifestyle modification program reduce cardiovascular disease risk factors and Framingham risk score in women with moderate-to-high risk of CVD?
Absolute Event Rate: 8.09% vs 21.67%
p-value: p=<0.01
A personalized lifestyle modification program significantly improved the 10-year cardiovascular Framingham risk score and systolic blood pressure in women at moderate-to-high risk of CVD over 3 months.
Supports personalized lifestyle programs in routine care for moderate-to-high risk women; extends RCT evidence for tailored CVD prevention.
Background Cardiovascular disease (CVD) remains the major cause of global mortality. Applying a comprehensive interventional program may reduce the incidence of cardiovascular disease and its complications. Objective This study compared the effects of a three-month intervention involving lifestyle modification and physical activity with standard care in women ≥30 years having a moderate to high risk of CVD, with respect to improving physical activity and cardiovascular disease risk factors at the National Guard Residential City in Jeddah, Saudi Arabia, in 2015. Methods The effects of this community-based lifestyle program were assessed through a randomized controlled trial from January 1st to September 6th, 2015. Women in the intervention group (n = 31) received health education, exercise training, and diet counselling as individuals and in groups according to the participant's risk. Women in the control group (n = 28) received one health education session at the screening site. The primary outcome was the proportion of women with moderate Framingham risk scores (FRS) reducing their risk by 10% and the proportion of women with high FRS reducing their risk by 25%. The secondary outcome was the proportion of women reducing their risk by ≥1 risk category. Results The mean participant age was 42 ± 8 years. At three-month's follow-up, reductions were greater in the intervention group and the difference between groups was statistically significant (p < 0.05). Lifestyle intervention program significantly reduced systolic blood pressure (-9.2 mmHg), blood glucose (-45 mg/dL) and Framingham risk score (-13.6). Linear regression analysis revealed a significant improvement in the Framingham risk score (p < 0.01). Conclusion In a population of women with moderate-to-high risk of CVD, a personalized lifestyle modification program showed positive association in improving the 10-year cardiovascular Framingham risk score after three months.
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Khouja et al. (2020) conducted an RCT in Moderate to high risk of cardiovascular disease (n=59). Personalized lifestyle modification program (health education, exercise training, diet counselling) vs. Standard care (one health education session) was evaluated on Framingham risk score at 3 months (p=<0.01). A personalized lifestyle modification program significantly reduced the 10-year cardiovascular Framingham risk score compared to standard care in women with moderate-to-high risk of cardiovascular disease.
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