Key result
A spectrofluorometric method for analyzing carvedilol in pharmaceutical preparations demonstrated high linearity (r > 0.997) and recovery (>98.4%) with a detection limit of 2.196 ng/mL.
Why the study?
The goal was to develop and apply a spectrofluorometric method for analyzing carvedilol in pharmaceutical preparations.
A simple, sensitive, and cost-effective spectrofluorometric method was successfully developed and validated for the quantitative analysis of carvedilol in pharmaceutical tablets.
May aid carvedilol assay development in pharma labs; leaves open routine adoption pending further validation.
The goal of this research is to develop a spectrofluorometric method for analyzing carvedilol in pharmaceutical preparations and apply this method to the formulations. The method’s calibration curve was plotted between 25 and 500 ng/mL. The mean calibration equation from six replicate experiments is y=1.8736x+7.7291. The correlation coefficient value was higher than 0.997 for the mean calibration curve. The trueness results were better than 2.09% and the precision results were less than 2.73% for carvedilol. The detection and quantitation limits were determined as 2.196 and 6.654 ng/mL, respectively. In addition, the method was used to study carvedilol in pharmaceutical preparations. The method had recovery values >98.4% for all samples in pharmaceutical preparations. The detection wavelength was optimized to maximize the sensitivity of the method. This method has good sensitivity with satisfactory results. Therefore, the method can be used in carvedilol analysis.
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Bilal Yılmaz (2022) studied this question. Spectrofluorometric method was evaluated on Method performance (calibration, trueness, precision, limits of detection and quantitation). A spectrofluorometric method for analyzing carvedilol in pharmaceutical preparations demonstrated high linearity (r > 0.997) and recovery (>98.4%) with a detection limit of 2.196 ng/mL.
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