Two patients with metastatic pheochromocytoma received chemotherapy with 5-fluorouracil, cyclophosphamide, and streptozotocin. A biochemical response occurred in one instance. A review of the literature and the results in the reported patients indicate cyclophosphamide and/or streptozotocin may have activity in this neoplasm.
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Bukowski et al. (1984) studied this question.
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