Key result
The cardiac cycle-synchronized component of skin sympathetic nerve activity decreased during head-up tilt in hyperthermia (P<0.017) and strongly correlated with cutaneous vascular conductance (r=0.817, P<0.0001).
Population
Young men
Comparison
Postural change from supine to 30 deg head-up… vs Supine position before and after warming
Design
Other
Authors
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Hypothesis-generating for heat syncope mechanisms; should not yet change clinical management of orthostatic intolerance.
Effect estimate: r=0.817
p-value: p=<0.0001
The skin sympathetic nerve activity component synchronized with the cardiac cycle appears to be involved in suppressing cutaneous vasodilatation during postural changes in hyperthermia, potentially preventing heat syncope.
Ogawa et al. (2016) studied Healthy (n=12). 30° head-up tilt during hyperthermia vs. Supine position / normothermia was evaluated on Correlation between cardiac cycle-synchronized skin sympathetic nerve activity (SSNA) and cutaneous vascular conductance (CVCchest) (r=0.817, p=<0.0001). The cardiac cycle-synchronized component of skin sympathetic nerve activity decreased during head-up tilt in hyperthermia (P<0.017) and strongly correlated with cutaneous vascular conductance (r=0.817, P<0.0001).
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