February 18, 1997Proceedings of the National Academy of SciencesOpen Access

Pleiotropic effects of a disrupted K + channel gene: Reduced body weight, impaired motor skill and muscle contraction, but no seizures

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Population

Kv3.1-/- mutant mice (homozygous), Kv3.1+/- (heterozygous), and wild-type littermates (n=101 F2 mice).

Comparison

Disruption of the fast activating, voltage-gated… vs Wild-type and heterozygous Kv3.1+/- littermates

Design

Preclinical

Follow-up

up to 3 months of age

Authors

CHChi S. HoCayman Chemical (United States)RGRobert W. GrangeVirginia Tech RJRolf H. JohoSouthwestern Medical Center

Discussion

Member takes

Overview

Kv3.1-null motor and growth phenotypes in mice without seizures caution against channel blockade; leaves open human translational relevance.

Structured PICO

Population

Kv3.1-/- mutant mice (homozygous), Kv3.1+/- (heterozygous), and wild-type littermates (n=101 F2 mice).

Intervention

Disruption of the fast activating, voltage-gated K+ channel Kv3.1 gene (Kv3.1-/- knockout)

Comparator

Wild-type and heterozygous Kv3.1+/- littermates

Outcome

Body weight, motor skill (rotarod test), spontaneous locomotor activity, muscle contraction properties, startle response, and seizure activitysurrogate

Disruption of the Kv3.1 potassium channel in mice leads to reduced body weight, impaired motor skills, and altered muscle contractility, but does not cause spontaneous seizures.

Cite This Study

Ho et al. (1997) studied this question.

synapsesocial.com/papers/6a7c7674a2188deaa4c29f2a https://doi.org/10.1073/pnas.94.4.1533

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February 18, 1997Proceedings of the National Academy of SciencesOpen Access

Pleiotropic effects of a disrupted K + channel gene: Reduced body weight, impaired motor skill and muscle contraction, but no seizures

View Full Paper

Ask AI

Bookmark

Population

Kv3.1-/- mutant mice (homozygous), Kv3.1+/- (heterozygous), and wild-type littermates (n=101 F2 mice).

Comparison

Disruption of the fast activating, voltage-gated… vs Wild-type and heterozygous Kv3.1+/- littermates

Design

Preclinical

Follow-up

up to 3 months of age

Authors

CHChi S. HoCayman Chemical (United States)RGRobert W. GrangeVirginia Tech RJRolf H. JohoSouthwestern Medical Center

Discussion

Member takes

Overview

Kv3.1-null motor and growth phenotypes in mice without seizures caution against channel blockade; leaves open human translational relevance.

Structured PICO

Population

Kv3.1-/- mutant mice (homozygous), Kv3.1+/- (heterozygous), and wild-type littermates (n=101 F2 mice).

Intervention

Disruption of the fast activating, voltage-gated K+ channel Kv3.1 gene (Kv3.1-/- knockout)

Comparator

Wild-type and heterozygous Kv3.1+/- littermates

Outcome

Body weight, motor skill (rotarod test), spontaneous locomotor activity, muscle contraction properties, startle response, and seizure activitysurrogate

Disruption of the Kv3.1 potassium channel in mice leads to reduced body weight, impaired motor skills, and altered muscle contractility, but does not cause spontaneous seizures.

Cite This Study

Ho et al. (1997) studied this question.

synapsesocial.com/papers/6a7c7674a2188deaa4c29f2a https://doi.org/10.1073/pnas.94.4.1533

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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