Key result
X-ray crystal structures of the intact E. coli ribosome reveal that the interface between the small and large ribosomal subunits rearranges in discrete steps along the ratcheting pathway.
Authors
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May guide ribosome-targeting antibiotic design; extends atomic models of prokaryotic translation ratcheting.
Zhang et al. (2009) studied this question. X-ray crystal structures of the intact E. coli ribosome reveal that the interface between the small and large ribosomal subunits rearranges in discrete steps along the ratcheting pathway.
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