Key result
Maternal adverse emotions during pregnancy significantly increased the risk of congenital heart disease in offspring (OR 2.650), alongside other factors like maternal exposure to polluted water and paternal active smoking.
Why the study?
Nonhereditary factors play an important role in congenital heart disease (CHD), but relevant parental nonhereditary exposure factors in northeastern Sichuan needed exploration.
Do parental nonhereditary exposure factors increase the risk of congenital heart disease in offspring?
Case-Control (n=644)
Yes
Do parental nonhereditary exposure factors increase the risk of congenital heart disease in offspring?
Odds Ratio: 2.65 (95% CI 1.903–3.692)
p-value: p=<0.001
Maternal adverse emotions, exposure to polluted water, and paternal active smoking are significant nonhereditary risk factors for congenital heart disease in offspring, while maternal nutrition supplementation is protective.
Nonhereditary factors play an important role in the occurrence of congenital heart disease (CHD). This study was to explore the possible parental nonhereditary exposure factors relevant to the occurrence of CHD in the northeastern Sichuan area. A total of 367 children with CHD and 367 children without congenital malformations aged 0 to 14 years old were recruited from the Affiliated Hospital of North Sichuan Medical College and Nanchong Central Hospital between March 2016 and November 2018. This study was designed as a case-control study with 1:1 frequency matching, in which the parents of cases and controls were interviewed with the same questionnaire according to the gestational age of the child, maternal age during pregnancy and the same maternal race/ethnicity. Then, 322 matched case-control pairs were analysed by SPSS 22. Thirty-one suspicious factors were entered into the binary logistic regression analysis after univariate regression analysis of 55 factors (alpha = 0.05). The analysis results showed that 7 factors were significantly associated with the occurrence of CHD. Thus, augmenting maternal mental healthcare, improving the quality of drinking water, obtaining adequate nutrition, maintaining a healthy physical condition during pregnancy, enhancing parents' level of knowledge and maintaining a healthy lifestyle may lower the occurrence of CHD.
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Liang et al. (2020) conducted a case-control in Congenital heart disease (n=644). Maternal adverse emotions during pregnancy vs. Absence of maternal adverse emotions during pregnancy was evaluated on Occurrence of congenital heart disease (OR 2.650, 95% CI 1.903-3.692, p=<0.001). Maternal adverse emotions during pregnancy significantly increased the risk of congenital heart disease in offspring (OR 2.650), alongside other factors like maternal exposure to polluted water and paternal active smoking.
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