Atrial fibrillation pharmacotherapy after hospital discharge between 1995 and 2004: a shift towards beta-blockers
Key result
Between 1995-1996 and 2003-2004, beta-blocker use after first-time atrial fibrillation increased from 7.4% to 44.3%, while use of digoxin, sotalol, and calcium-channel blockers decreased.
Why the study?
How did the pharmacotherapy of atrial fibrillation change between 1995 and 2004 in Denmark?
Population
108,791 Danish patients discharged following first-time atrial fibrillation who survived 30 days after…
Design
Cohort
Authors
Discussion
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Implication
Prescribing patterns for incident AF shifted toward beta-blockers in Denmark; extends historical trend data but leaves open effects on outcomes.
Study Design
Type
Observational (n=108,791)
Multicenter
Yes
Structured PICO
How did the pharmacotherapy of atrial fibrillation change between 1995 and 2004 in Denmark?
P
Population
108,791 Danish patients surviving 30 days after discharge for first-time atrial fibrillation between 1995 and 2004.
E
Exposure
Pharmacotherapy for atrial fibrillation (beta-blockers, amiodarone, nondihydropyridine calcium-channel blockers, digoxin, sotalol, class 1C antiarrhythmics, oral anticoagulants)
O
Outcome
Trends in the use of specific pharmacotherapies for atrial fibrillation between 1995 and 2004
Main Result
Absolute Event Rate: 44.3% vs 7.4%
Between 1995 and 2004, pharmacotherapy for atrial fibrillation in Denmark shifted significantly towards increased use of beta-blockers and oral anticoagulants, with a concurrent decrease in digoxin and sotalol.
Cite This Study
Hansen et al. (2008) conducted an observational in First-time atrial fibrillation (n=108,791). Discharge in 2003-2004 vs. Discharge in 1995-1996 was evaluated on Beta-blocker use. Between 1995-1996 and 2003-2004, beta-blocker use after first-time atrial fibrillation increased from 7.4% to 44.3%, while use of digoxin, sotalol, and calcium-channel blockers decreased.