Key result
Age (RR 1.8 per decade), female sex (RR 1.6), hypertension (RR 2.0), systolic BP >160 mm Hg (RR 2.3), and prior stroke/TIA (RR 2.9) independently increased ischemic stroke risk in AF on aspirin.
Why the study?
What clinical factors are associated with ischemic stroke in patients with nonvalvular atrial fibrillation taking aspirin?
Population
2,012 participants with nonvalvular atrial fibrillation from the Stroke Prevention in Atrial Fibrillation…
Design
Cohort
Follow-up
mean 2.0 years
Authors
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May aid stroke risk stratification in aspirin-treated AF; extends prior observations but hypothesis-generating and should not yet change practice.
Observational (n=2,012)
What clinical factors are associated with ischemic stroke in patients with nonvalvular atrial fibrillation taking aspirin?
Clinical factors such as age, female sex, hypertension, and prior stroke/TIA can stratify ischemic stroke risk in patients with nonvalvular atrial fibrillation treated with aspirin.
Hart et al. (1999) conducted an observational in Nonvalvular atrial fibrillation (n=2,012). Aspirin was evaluated on Ischemic stroke. Age (RR 1.8 per decade), female sex (RR 1.6), hypertension (RR 2.0), systolic BP >160 mm Hg (RR 2.3), and prior stroke/TIA (RR 2.9) independently increased ischemic stroke risk in AF on aspirin.
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