Population
Pancreatic beta-cells isolated from NOD mice and NOD insulinoma tumor cells (NIT-1)
Comparison
Pharmacological analyses using channel blockers… vs Pancreatic beta-cells from nondiabetic prone mice
Design
Preclinical
Authors
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Abnormally expressed LVA channels may drive beta-cell calcium overload in NOD diabetes models; leaves open therapeutic relevance in humans.
Abnormally expressed LVA calcium channels in NOD mouse beta-cells lead to higher intracellular free calcium, potentially contributing to their pathogenesis.
Wang et al. (1996) studied this question.
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