Why the study?
Does antihypertensive therapy (such as propranolol) improve prognosis and preserve renal function in patients with chronic glomerulonephritis and hypertension?
Does antihypertensive therapy (such as propranolol) improve prognosis and preserve renal function in patients with chronic glomerulonephritis and hypertension?
Antihypertensive therapy, including propranolol, improves prognosis in hypertensive chronic glomerulonephritis but requires caution in patients with renal failure due to the risk of inducing heart failure.
Supports cautious propranolol use for BP control in non-failure CGN; leaves open prognostic benefit pending randomized trials.
Statistical analysis of the realtion between blood pressure and renal function in 421 patients with CGN, referred to the Second Internal Medicine at Nihon University Hospital, and in 253 Hypertensive patients with CGN by questionaires sent to 29 Medical Universities were investigated. The relationship between survival rate and blood pressure of 84 patients with CGN in Surugadai Nihon University Hospital was also examined. These data show that antihypertensive therapy for CGN with hypertension has an important effect on prognosis. Propranolol was given to 10 hypertensive patients with CGN and hypotensive effect on renal function was observed. Our experience suggests that propranolol may be useful for treating a high renin component in the hypertension with non renal failure, and renal function does not become worse. But in renal failure, propranolol therapy must be used carefully because of inducement to cardiac failure.
No takes yet. Share an insight, caveat, or question.
Nagao Kajiwara (1975) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: