Key result
In a generic analytical model of Brownian rotors, dynamics and mechanical efficiency depend on the magnitude of stochastic motion driven by free energy difference and its rectification.
The study provides an analytical model explaining how free energy profiles affect the rectification and efficiency of Brownian rotors like the F-ATP synthase.
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Model refines F-ATP synthase efficiency predictions; leaves open validation in cardiac bioenergetics.
Brownian rotors play an important role in biological systems and in future nanotechnological applications. However the mechanisms determining their dynamics, efficiency, and performance remain to be characterized. Here the F0 portion of the F-ATP synthase is considered as a paradigm of the Brownian rotor. In a generic analytical model we analyze the stochastic rotation of F0-like motors as a function of the driving free energy difference and of the free energy profile the rotor is subjected to. The latter is composed of the rotor interaction with its surroundings, of the free energy of chemical transitions, and of the workload. The dynamics and mechanical efficiency of the rotor depend on the magnitude of its stochastic motion driven by the free energy difference and its rectification on the reaction-diffusion path. We analyze which free energy profiles provide maximum flow and how their arrangement on the underlying reaction-diffusion path affects rectification and--by this--the efficiency.
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A 2008 study studied this question. Generic analytical model of Brownian rotors was evaluated on Dynamics and mechanical efficiency of the rotor. In a generic analytical model of Brownian rotors, dynamics and mechanical efficiency depend on the magnitude of stochastic motion driven by free energy difference and its rectification.
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