Key result
Elevated mean arterial pressure at CRRT initiation was associated with a lower risk of mortality in acute kidney injury patients (P<0.001).
Why the study?
Maintenance of appropriate mean arterial pressure is important for critically ill patients, but its association with prognosis in acute kidney injury patients receiving continuous renal replacement therapy is unclear.
Is elevated mean arterial pressure associated with a lower risk of mortality in acute kidney injury patients receiving continuous renal replacement therapy?
Cohort (n=1,144)
Is elevated mean arterial pressure associated with a lower risk of mortality in acute kidney injury patients receiving continuous renal replacement therapy?
p-value: p=<0.001
Elevated mean arterial pressure at the initiation of continuous renal replacement therapy is associated with lower 28- and 90-day mortality in critically ill patients with acute kidney injury.
OBJECTIVE: maintenance of an appropriate mean arterial pressure (MAP) is important for critically ill patients. However, the association between MAP and prognosis in acute kidney injury (AKI) patients receiving continuous renal replacement therapy (CRRT) is thus far unclear. MATERIALS AND METHODS: a total of 1,144 AKI patients who had received CRRT between January 2009 and September 2016 were enrolled and their MAP was measured at CRRT initiation. Patients were categorized into four groups (Quartile 1: MAP < 67.3 mmHg; Quartile 2: 67.3 ≤ MAP < 76.7 mmHg; Quartile 3: 76.7 ≤ MAP < 86.3 mmHg; Quartile 4: MAP ≥ 86.3 mmHg), and 28- and 90-day mortality rates were compared. RESULTS: < 0.001). CONCLUSION: MAP is a valuable parameter for predicting mortality in AKI patients who are receiving CRRT.
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Sheng et al. (2023) conducted a cohort in Acute kidney injury (AKI) receiving continuous renal replacement therapy (CRRT) (n=1,144). Elevated mean arterial pressure vs. Lower mean arterial pressure quartiles was evaluated on 28- and 90-day mortality (p=<0.001). Elevated mean arterial pressure at CRRT initiation was associated with a lower risk of mortality in acute kidney injury patients (P<0.001).
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