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July 1, 2016Cell MetabolismOpen Access

Glucocorticoids Acutely Increase Brown Adipose Tissue Activity in Humans, Revealing Species-Specific Differences in UCP-1 Regulation

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Key result

The glucocorticoid prednisolone acutely increased brown adipose tissue activity, supraclavicular skin temperature, and energy expenditure during mild cold exposure in lean healthy men.

Why the study?

Does prednisolone acutely increase brown adipose tissue activity in lean healthy men?

Population

Lean healthy men (in vivo) and primary human and murine brown/beige adipocytes (in vitro)

Design

Preclinical

Follow-up

Acute

Authors

LRLynne RamageMAMurat AkyolAFAlison Fletcher

Discussion

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Overview

No immediate clinical application; leaves open species-specific glucocorticoid effects on human BAT versus rodents.

Structured PICO

Does prednisolone acutely increase brown adipose tissue activity in lean healthy men?

P
Population
Lean healthy men undergoing mild cold exposure to assess brown adipose tissue activity.
I
Intervention
Prednisolone (glucocorticoid)
O
Outcome
Brown adipose tissue (BAT) activity measured by (18)fluorodeoxyglucose uptake using PET/CTsurrogate

Glucocorticoids acutely increase brown adipose tissue activity in humans, demonstrating a highly species-specific regulation of BAT function compared to rodents.

Cite This Study

Ramage et al. (2016) studied Healthy. Prednisolone was evaluated on Brown adipose tissue activity ((18)fluorodeoxyglucose uptake). The glucocorticoid prednisolone acutely increased brown adipose tissue activity, supraclavicular skin temperature, and energy expenditure during mild cold exposure in lean healthy men.

synapsesocial.com/papers/6a7c877389e1533e368b052dhttps://doi.org/10.1016/j.cmet.2016.06.011
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Obesity and Gender Influence Cortisol Secretion and Metabolism in Man1998 · 352 citations
  2. 2Infrared thermography in the detection of brown adipose tissue in humans2014 · 102 citations
  3. 3Cortisol Release From Adipose Tissue by 11β-Hydroxysteroid Dehydrogenase Type 1 in Humans2008 · 125 citations
  4. 4High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans2009 · 1,858 citations
  5. 5Identification and Importance of Brown Adipose Tissue in Adult Humans2009 · 4,460 citations