Clinical presentation, aetiology and outcome of infective endocarditis. Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry: a prospective cohort study
Key result
Infective endocarditis carries ~17% in-hospital mortality, driven largely by heart failure and unperformed indicated surgery.
- n=3,116
Population
3116 adult patients with a diagnosis of infective endocarditis based on ESC 2015 diagnostic criteria…
Design
Cohort
Follow-up
In-hospital
Authors
Discussion
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Implication
Infective endocarditis remains a life-threatening disease with a 17.1% in-hospital mortality rate, and failure to perform indicated surgery is an independent predictor of death.
Key Points
- To evaluate the contemporary clinical characteristics, diagnostic imaging, microbiology, and in-hospital management outcomes of patients diagnosed with infective endocarditis.
- Prospective multicenter cohort study of 3,116 adult patients across 156 hospitals in 40 countries diagnosed between January 2016 and March 2018 using ESC 2015 criteria.
- Clinical, microbiological, and multimodality imaging data—including echocardiography, CT, and 18F-FDG PET/CT—were systematically recorded.
- Infective endocarditis presented as native valve in 56.6%, prosthetic valve in 30.1%, and device-related in 9.9% of patients, with staphylococci being the most frequent pathogen (44.1%).
- 18F-FDG PET/CT revealed abnormal cardiac uptake in 42.9% of examined patients, showing higher sensitivity in prosthetic valve endocarditis (66.8%) compared with native valve (28.0%) and device-related cases (16.3%).
- Cardiac surgery was indicated in 69.3% of patients but completed in only 73.9% of indicated cases, with overall in-hospital mortality reaching 17.1%.
Study Design
Type
Cohort (n=3,116)
Multicenter
Yes
Structured PICO
P
Population
3,116 adult patients with infective endocarditis admitted to 156 hospitals across 40 countries to evaluate clinical management and outcomes.
O
Outcome
In-hospital deathhard clinical
Infective endocarditis remains a life-threatening disease with a 17.1% in-hospital mortality rate, and failure to perform indicated surgery is an independent predictor of death.
Cite This Study
Habib et al. (2019) conducted a cohort in Infective endocarditis (n=3,116). Infective endocarditis was evaluated on In-hospital death. Infective endocarditis was associated with an in-hospital mortality rate of 17.1%, with independent predictors including heart failure, abscess, and failure to undertake indicated surgery.