Key result
In rats with blocked AT1 and AT2 receptors, the Mas receptor antagonist A779 showed a tendency to increase renal blood flow per kidney weight in males (P=0.08) but not in females.
Population
Anaesthetized male and female Wistar rats
Comparison
MasR blockade in the presence of AT1R and AT2R… vs Saline vehicle in the presence of AT1R and AT2R…
Design
Preclinical
Authors
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May not inform human renal therapy; leaves open sex-specific MasR-Ang II crosstalk in animal models.
p-value: p=0.08
Co-blockade of AT1R, AT2R, and MasR may alter renal blood flow more in male than female rats, supporting crosstalk between MasR and Ang II receptors in renal circulation.
Mansoori et al. (2016) studied Normal renal hemodynamics (n=49). Mas receptor antagonist (A779) vs. Vehicle (saline) was evaluated on Renal blood flow per wet kidney tissue weight (RBF/KW) (p=0.08). In rats with blocked AT1 and AT2 receptors, the Mas receptor antagonist A779 showed a tendency to increase renal blood flow per kidney weight in males (P=0.08) but not in females.
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