Key result
Endothelial dysfunction, inflammation, and apoptosis interact to drive microvascular damage in type 2 diabetes.
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Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2 diabetes. The imbalance in repair and injury (hyperglycemia, hypertension, dyslipidemia) results in microvascular changes, including apoptosis of microvascular cells, ultimately leading to diabetes related complications. This review summarizes the mechanisms by which the interplay between endothelial dysfunction, inflammation, and apoptosis may cause (micro)vascular damage in patients with diabetes mellitus.
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Oever et al. (2010) conducted a review in Diabetes mellitus (specifically obesity-related type 2 diabetes). Endothelial dysfunction, inflammation, and apoptosis was evaluated on (Micro)vascular damage and diabetes-related complications. Endothelial dysfunction, inflammation, and apoptosis interplay to cause microvascular cell apoptosis and vascular damage in patients with type 2 diabetes mellitus.
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