What question did this study set out to answer?

To review epidemiological and physiological evidence linking fetal nutrient deprivation to the developmental origins of chronic adult disorders.

August 1, 1998Clinical Science

In utero programming of chronic disease

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Implication

Review uncovers links between fetal undernutrition and adult chronic conditions in humans, suggesting early metabolic adaptations permanently shape long-term disease risk.

Key Points

To review epidemiological and physiological evidence linking fetal nutrient deprivation to the developmental origins of chronic adult disorders.
Reviewed observational and cohort evidence evaluating fetal undernutrition and growth restriction.
Assessed long-term developmental adaptations affecting tissue structure, organ development, and metabolic regulation.
Fetal adaptation to restricted nutrient supplies induces permanent changes in physical organ structure and metabolic pathways.
Impaired fetal growth and undernutrition consistently link to an increased risk of coronary heart disease, stroke, hypertension, and type 2 diabetes in adult life.

Cite This Study

A 1998 study studied this question.

synapsesocial.com/papers/6a7c9097fecf32cfa0610e52 https://doi.org/10.1042/cs0950115

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Implication

Review uncovers links between fetal undernutrition and adult chronic conditions in humans, suggesting early metabolic adaptations permanently shape long-term disease risk.

In utero programming of chronic disease

Discussion

Member takes

Implication

Key Points

Cite This Study

In utero programming of chronic disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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