Why the study?
Does a recombinant PPRV expressing FMDV VP1 induce protective immune responses against PPRV and FMDV in goats?
Does a recombinant PPRV expressing FMDV VP1 induce protective immune responses against PPRV and FMDV in goats?
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A novel recombinant PPRV expressing FMDV VP1 shows potential as a dual live vectored vaccine against both PPRV and FMDV in goats.
Peste des petits ruminants (PPR) and foot-and-mouth disease (FMD) are both highly contagious diseases of small domestic and wild ruminants caused by the PPR virus (PPRV) and the FMD virus (FMDV). In this study, a recombinant PPRV expressing the FMDV VP1 gene (rPPRV/VP1) was generated and FMDV VP1 expression did not impair replication of the recombinant virus in vitro and immunogenicity in inducing neutralizing antibody against PPR in goats. Vaccination with one dose of rPPRV/VP1 induced FMDV neutralizing antibody in goats and protected them from challenge with virulent FMDV. Our results suggest that the recombinant PPRV expressing the FMDV VP1 protein is a potential dual live vectored vaccine against PPRV and FMDV.
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Yin et al. (2014) studied Healthy goats susceptible to FMDV and PPRV (n=10). rPPRV/VP1 (recombinant PPRV expressing FMDV VP1) vs. N75/1 (live PPRV attenuated vaccine) was evaluated on Clinical lesion score post-challenge with virulent FMDV (p=<0.01).
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