Genetic Testing for Cardiovascular Disease Susceptibility: A Useful Clinical Management Tool or Possible Misinformation?
Why the study?
Does genetic susceptibility testing improve the prediction of cardiovascular disease risk compared to traditional risk factors?
Population
Individuals at risk for cardiovascular disease (CVD)
Comparison
Genetic susceptibility testing for CVD risk vs Traditional risk assessment
Design
Review
Authors
Discussion
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Member takes
Implication
Genetic testing adds no value to traditional CVD risk prediction; hypothesis-generating for refined scores overcoming multigenic and environmental limits.
Structured PICO
Does genetic susceptibility testing improve the prediction of cardiovascular disease risk compared to traditional risk factors?
P
Population
Individuals at risk for cardiovascular disease (CVD)
I
Intervention
Genetic susceptibility testing for CVD risk
C
Comparator
Traditional risk assessment (personal characteristics and plasma risk-trait levels)
O
Outcome
Prediction of clinical outcome / CVD risk
Direct-to-consumer genetic testing for CVD risk currently offers little predictive value over traditional clinical and biochemical risk factors.
Cite This Study
Humphries et al. (2004) studied this question.