Key result
Angiotensin II infusion induced prominent cardiac hypertrophy and fibrosis in wild-type mice, but these effects were abolished in PLZF knockout mice despite comparable elevations in blood pressure.
Why the study?
Does PLZF gene deletion prevent Angiotensin II-induced cardiac hypertrophy in mice?
Population
10-12 weeks old PLZF knockout and wild-type male mice on a C57BL/6 genetic background, as well as AT2…
Comparison
Angiotensin II infusion at a rate of 4.2… vs Saline pellet infusion, or Ang II co-infused…
Design
Preclinical
Follow-up
3 weeks (21 days) or 60 days
Authors
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PLZF may mediate Ang II cardiac effects in mice; hypothesis-generating for targeted therapies pending human studies.
Does PLZF gene deletion prevent Angiotensin II-induced cardiac hypertrophy in mice?
p-value: p=<0.05
PLZF is a crucial transcription factor that mediates Angiotensin II-induced cardiac hypertrophy through the AT2 receptor by up-regulating GATA4 expression.
Wang et al. (2012) studied Cardiac hypertrophy (n=22). Angiotensin II infusion vs. Saline infusion / PLZF knockout vs wild-type was evaluated on Cardiac hypertrophy and fibrosis (p=<0.05). Angiotensin II infusion induced prominent cardiac hypertrophy and fibrosis in wild-type mice, but these effects were abolished in PLZF knockout mice despite comparable elevations in blood pressure.
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