November 1, 1999Arteriosclerosis Thrombosis and Vascular Biology

Focal Expression of Angiotensin II Type 1 Receptor and Smooth Muscle Cell Proliferation in the Neointima of Experimental Vein Grafts

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Population

Rat model of experimental vein grafts with and without eddy flow

Comparison

Losartan or prevention of eddy flow vs Vein grafts without losartan or with eddy flow

Design

Preclinical

Follow-up

30 days

Authors

SLS. Q. LiuNorthwestern University

Discussion

Member takes

Implication

Losartan attenuates experimental vein graft SMC proliferation; leaves open translation to human bypass outcomes.

Structured PICO

Population

Rat model of experimental vein grafts with and without eddy flow

Intervention

Losartan or prevention of eddy flow

Comparator

Vein grafts without losartan or with eddy flow

Outcome

Expression of AT1 mRNA and protein, and rate of smooth muscle cell (SMC) proliferation in the neointima at days 5, 10, 20, and 30surrogate

Eddy flow upregulates the AT1 receptor, mediating focal smooth muscle cell proliferation in the neointima of experimental vein grafts, which can be attenuated by losartan.

Cite This Study

S. Q. Liu (1999) studied this question.

synapsesocial.com/papers/6a7c91f10bb6134e42cf7e19 https://doi.org/10.1161/01.atv.19.11.2630

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Focal Expression of Angiotensin II Type 1 Receptor and Smooth Muscle Cell Proliferation in the Neointima of Experimental Vein Grafts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Focal Expression of Angiotensin II Type 1 Receptor and Smooth Muscle Cell Proliferation in the Neointima of Experimental Vein Grafts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider