What question did this study set out to answer?

To determine the evolutionary mechanisms underlying the sporadic distribution of the ACE1 secondary metabolism gene cluster across filamentous fungi.

January 24, 2008Genome biologyOpen Access

Evidence for horizontal transfer of a secondary metabolite gene cluster between fungi

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Authors

NKNora KhaldiEricsson (Ireland)JCJérôme CollemareUniversity of Groningen MLMarc‐Henri LebrunCentre National de la Recherche Scientifique

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Implication

Phylogenetic analysis reveals horizontal transfer of an ACE1-like metabolic gene cluster into Aspergillus clavatus, indicating interspecies transfer drives fungal chemical diversity.

Key Points

To determine the evolutionary mechanisms underlying the sporadic distribution of the ACE1 secondary metabolism gene cluster across filamentous fungi.
Identified homologous ACE1-like secondary metabolite gene clusters in the genomes of the ascomycetes Magnaporthe grisea, Chaetomium globosum, Stagonospora nodorum, and Aspergillus clavatus.
Performed gene-by-gene phylogenetic analyses to reconstruct evolutionary histories of individual cluster genes, tracking duplications, losses, and potential transfer events.
Identified that ACE1-like cluster evolution in C. globosum and M. grisea involved complex successive duplication events, including tandem duplication within the M. grisea lineage.
Determined that at least five of the six genes in the homologous A. clavatus cluster originated via horizontal transfer from a donor closely related to M. grisea rather than through extensive independent gene losses.

Cite This Study

Khaldi et al. (2008) studied this question.

synapsesocial.com/papers/6a7c9358cc6f1443deba5bbf https://doi.org/10.1186/gb-2008-9-1-r18

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Implication

Phylogenetic analysis reveals horizontal transfer of an ACE1-like metabolic gene cluster into Aspergillus clavatus, indicating interspecies transfer drives fungal chemical diversity.

Evidence for horizontal transfer of a secondary metabolite gene cluster between fungi

Discussion

Member takes

Implication

Key Points

Cite This Study

Evidence for horizontal transfer of a secondary metabolite gene cluster between fungi

Discussion

Member takes

Implication

Key Points

Cite This Study

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