What question did this study set out to answer?

Provide an updated, comprehensive catalog, chromosomal mapping, and standardized evolution-based nomenclature system for the cytochrome P450 gene superfamily.

January 1, 1993DNA and Cell Biology

The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature

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Authors

DNDavid R. NelsonUniversity of Tennessee Health Science Center TKT. KamatakiNovartis (Switzerland)DWDavid J. WaxmanBoston University

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Implication

Comparative genomic analysis reveals 221 cytochrome P450 genes across 42 species, providing a standardized evolutionary nomenclature and chromosomal mapping framework.

Key Points

Provide an updated, comprehensive catalog, chromosomal mapping, and standardized evolution-based nomenclature system for the cytochrome P450 gene superfamily.
Cataloged and annotated 221 cytochrome P450 genes and 12 putative pseudogenes identified across 31 eukaryotes (including 11 mammals and 3 plants) and 11 prokaryotes as of late 1992.
Mapped 22 mammalian subfamilies within human (17 subfamilies) and mouse (15 subfamilies) genomes while compiling database accession numbers and expressed sequence tags (ESTs).
Identified 36 distinct P450 gene families, with 12 ubiquitous across evaluated mammals, each subfamily generally representing a cluster of tightly linked genes.
Defined the standardized root nomenclature using italicized 'CYP' for human and 'Cyp' for mouse, followed by Arabic numbers for family and gene, and letters for subfamily.
Determined that the superfamily originated over 3.5 billion years ago with nonlinear evolutionary rates, highlighting convergent evolution with the nitric oxide synthase family.

Cite This Study

Nelson et al. (1993) studied this question.

synapsesocial.com/papers/6a7c94a4076dbfca02ba5bc9 https://doi.org/10.1089/dna.1993.12.1

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Implication

Comparative genomic analysis reveals 221 cytochrome P450 genes across 42 species, providing a standardized evolutionary nomenclature and chromosomal mapping framework.

The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature

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Cite This Study

The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature

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Implication

Key Points

Cite This Study

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