Why the study?
Does simvastatin attenuate chronic hypoxic pulmonary hypertension in rats?
Population
Male adult Sprague-Dawley rats
Comparison
Simvastatin 20 mg/kg ip once a day for 14 days… vs Hypoxia alone, normoxia alone, and normoxia plus…
Design
Preclinical
Follow-up
14 days
Authors
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Attenuates hypoxic PH in rats; leaves open translation to human pulmonary hypertension therapy.
Does simvastatin attenuate chronic hypoxic pulmonary hypertension in rats?
Simvastatin potently attenuates chronic hypoxic pulmonary hypertension, right ventricular hypertrophy, and vascular remodeling in a rat model, independent of eNOS enhancement.
Girgis et al. (2003) studied this question.
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