Key result
Heparin-induced multiple electrode aggregometry accurately diagnosed heparin-induced thrombocytopenia with a sensitivity of 90%, specificity of 100%, and AUC of 0.98 (95% CI, 0.95-1.0).
Why the study?
Overdiagnosis of heparin-induced thrombocytopenia is an unresolved issue in the ICU, and standard platelet function assays are not readily available, technically difficult, and slow.
Does heparin-induced multiple electrode aggregometry accurately diagnose heparin-induced thrombocytopenia in ICU patients suspected of the condition?
Population
Patients suspected for heparin-induced thrombocytopenia in medical or surgical ICUs across 35 medical centers
Comparison
Heparin-induced multiple electrode aggregometry vs serotonin release assay and clinical HIT diagnosis
Design
Observational prospective study across 35 medical centers
Authors
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May aid HIT diagnosis in this cohort; leaves open prospective validation before routine use.
Observational
Yes
Does heparin-induced multiple electrode aggregometry accurately diagnose heparin-induced thrombocytopenia in ICU patients suspected of the condition?
Effect estimate: AUC 0.98 (95% CI 0.95-1.0)
Heparin-induced multiple electrode aggregometry is a highly sensitive and specific rapid functional assay that performs comparably to the gold standard serotonin release assay for diagnosing HIT in critically ill patients.
Gkalea et al. (2018) conducted an observational in Heparin-induced thrombocytopenia. Heparin-induced multiple electrode aggregometry vs. Serotonin release assay was evaluated on Heparin-induced thrombocytopenia diagnosis (AUC 0.98, 95% CI 0.95-1.0). Heparin-induced multiple electrode aggregometry accurately diagnosed heparin-induced thrombocytopenia with a sensitivity of 90%, specificity of 100%, and AUC of 0.98 (95% CI, 0.95-1.0).
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