May 28, 2009Heart
Potentially modifiable risk factors associated with myocardial infarction in China: the INTERHEART China study
Key result
Diabetes (OR 5.10), depression (OR 2.27), and permanent stress (OR 2.67) had significantly stronger associations with myocardial infarction in China compared to other regions (p<0.001).
Why the study?
What are the associations between potentially modifiable risk factors and myocardial infarction in China?
Population
Patients with first acute myocardial infarction and age- and sex-matched controls from 26 centres in China.
Design
Case-control
Authors
Discussion
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Implication
Supports targeted diabetes and psychosocial screening in China; extends global MI data but remains hypothesis-generating pending prospective studies.
Study Design
Type
Case-Control (n=6,086)
Multicenter
Yes
Structured PICO
What are the associations between potentially modifiable risk factors and myocardial infarction in China?
P
Population
6,086 participants comprising 3,030 patients with first acute MI and 3,056 age- and sex-matched controls from 26 centers in China.
C
Comparator
Age- and sex-matched controls without myocardial infarction
O
Outcome
Association of nine INTERHEART cardiovascular risk factors with myocardial infarctionhard clinical
Main Result
Odds Ratio: 5.1
p-value: p=<0.001
Diabetes and psychosocial factors have particularly strong associations with the risk of myocardial infarction in China compared to other regions, highlighting targets for regional cardiovascular prevention.
Cite This Study
Teo et al. (2009) conducted a case-control in myocardial infarction (n=6,086). Cardiovascular risk factors (e.g., diabetes, depression, permanent stress) vs. Age- and sex-matched controls without MI was evaluated on Myocardial infarction (OR 5.10, p=<0.001). Diabetes (OR 5.10), depression (OR 2.27), and permanent stress (OR 2.67) had significantly stronger associations with myocardial infarction in China compared to other regions (p<0.001).