Key result
Each percentage point increase in mean HbA1c was associated with a 31% increased risk for any-CVD and a 42% increased risk for MACE in patients with type 1 diabetes.
Why the study?
What are the risk factors for cardiovascular disease in patients with type 1 diabetes?
Population
Patients with type 1 diabetes from the Diabetes Control and Complications Trial (DCCT) cohort
Design
Cohort
Follow-up
mean 27 years
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Reinforces HbA1c monitoring for CVD risk in type 1 diabetes; extends observational data but remains hypothesis-generating.
Cohort
What are the risk factors for cardiovascular disease in patients with type 1 diabetes?
Effect estimate: 31% increase for any-CVD, 42% increase for MACE per 1% increase in HbA1c
In patients with type 1 diabetes, hyperglycemia (HbA1c) is a major risk factor for cardiovascular disease, second only to age.
A 2016 study conducted a cohort in Type 1 diabetes. Mean HbA1c was evaluated on Major atherosclerotic cardiovascular events (MACE) and any-CVD (31% increase for any-CVD, 42% increase for MACE per 1% increase in HbA1c). Each percentage point increase in mean HbA1c was associated with a 31% increased risk for any-CVD and a 42% increased risk for MACE in patients with type 1 diabetes.
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