Key result
Sinoaortic denervation in conscious rats significantly increased the amplitude and duration of blood pressure V-shaped waves and reduced their frequency compared to sham operation.
Why the study?
Does sinoaortic denervation alter blood pressure V-shaped waves in conscious Sprague-Dawley rats?
Does sinoaortic denervation alter blood pressure V-shaped waves in conscious Sprague-Dawley rats?
Sinoaortic denervation in rats enhances blood pressure V-shaped waves, increasing blood pressure variability without altering mean blood pressure, likely due to depressed sympathetic regulation.
Answers are grounded in this paper and cite their sources.
Supports baroreflex role in blood pressure variability; hypothesis-generating and leaves open human relevance.
A hemodynamic feature of chronic sinoaortic-denervated (SAD) rats is the increase in blood pressure variability (BPV) without significant changes in the average level of blood pressure (BP). The current study was designed to investigate the changes in BP V-shaped waves (V waves) in SAD rats. Sprague-Dawley (SD) rats were divided into 2 groups: SAD rats and sham-operated rats (n=13). Hemodynamics measurements were obtained in conscious, freely moving rats, four weeks after sinoaortic denervation or sham operation. V wave indices were evaluated in rats in both conscious and quiet states. Additionally, normal and high BPV was simulated by the production of V waves with different amplitudes. The results showed that the V wave amplitude was dramatically increased, with a significantly prolonged duration and reduced frequency in SAD rats. V wave BPV in SAD rats was significantly increased, though BP remained unchanged. The twenty-four hour BPV in all rats was positively correlated with amplitude, duration time and V wave BPV and negatively correlated with frequency. The systolic BP spectral powers in the low frequency range (0.38-0.45 Hz) were significantly reduced in the V waves of SAD rats. Moreover, there was a remarkable increase in mean BPV and a normal mean BP after simulating high BPV in SAD rats. These results suggest that enhancement of V waves might be a waveform character of BP in SAD rats in both the conscious and quiet states. These types of V waves appear to be related to a depression of sympathetic regulation of BP induced by sinoaortic denervation.
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Chang et al. (2016) studied High blood pressure variability (Sinoaortic denervation model) (n=26). Sinoaortic denervation vs. Sham operation was evaluated on V wave amplitude, duration time, and frequency (p=<0.01). Sinoaortic denervation in conscious rats significantly increased the amplitude and duration of blood pressure V-shaped waves and reduced their frequency compared to sham operation.
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