December 1, 1991AJP Heart and Circulatory Physiology
Role of sinoaortic afferents in modulating BP and pulse-interval spectral characteristics in unanesthetized cats
Population
9 unanesthetized cats
Comparison
Sinoaortic denervation (SAD) vs Baseline (before SAD)
Design
Preclinical
Follow-up
7-10 days
Authors
Discussion
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Implication
Sinoaortic denervation findings in cats warrant no clinical changes; leaves open baroreflex contributions to human BP and pulse-interval spectra.
Key Points
- This research aims to investigate how sinoaortic denervation affects blood pressure and pulse-interval variability in unanesthetized cats.
- Nine unanesthetized cats underwent sinoaortic denervation.
- Intra-arterial blood pressure was monitored before and 7-10 days post-denervation.
- Spectral powers were calculated for various frequency bands using fast Fourier transform.
- Sinoaortic denervation increased systolic blood pressure variance and decreased pulse-interval variance.
- Marked reductions in all pulse-interval powers were observed, alongside an increase in low frequency blood pressure power.
- Diastolic blood pressure powers showed similar patterns after sinoaortic denervation.
Structured PICO
P
Population
9 unanesthetized cats
I
Intervention
Sinoaortic denervation (SAD)
C
Comparator
Baseline (before SAD)
O
Outcome
Blood pressure (BP) and pulse-interval (PI) spectral characteristics (variance and spectral powers)surrogate
Sinoaortic denervation in cats reduces all pulse-interval fluctuations but has variable effects on different blood pressure spectral components.
Cite This Study
Rienzo et al. (1991) studied this question.