June 1, 1999AJP Heart and Circulatory Physiology
Effect of sinoaortic denervation on frequency-domain estimates of baroreflex sensitivity in conscious cats
Key result
Sinoaortic denervation markedly reduced baroreflex sensitivity in mid-frequency (-65.6%) and high-frequency (-79.9%) regions (P<0.01), showing the method reflects baroreflex modulation in MF only.
Population
13 conscious cats (8 undergoing sinoaortic denervation, 5 sham-operated)
Comparison
Sinoaortic denervation (SAD) vs Intact state (baseline) and sham-operated cats
Design
Preclinical
Follow-up
7-10 days
Authors
Discussion
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Implication
Questions spectral coherence specificity for baroreflex assessment; leaves open whether frequency-domain indices should supplant sequence methods in research.
Structured PICO
P
Population
13 conscious cats (8 undergoing sinoaortic denervation and 5 sham-operated) studied to assess baroreflex sensitivity.
I
Intervention
Sinoaortic denervation (SAD)
C
Comparator
Intact state (baseline) and sham-operated cats
O
Outcome
Sensitivity of baroreceptor-heart rate reflex assessed by the square root of the ratio of pulse interval and systolic blood pressure spectral powers (alpha) in mid-frequency (MF) and high-frequency (HF) regions, and coherence between themsurrogate
Main Result
p-value: p=< 0.01
Frequency-domain analysis specifically reflects baroreflex modulation of heart rate in the mid-frequency region, but not purely in the high-frequency region, in conscious cats.
Cite This Study
Mancia et al. (1999) studied this question. Sinoaortic denervation vs. Intact state and sham-operated cats was evaluated on Sensitivity of baroreceptor-heart rate reflex (alpha-MF and alpha-HF) (p=< 0.01). Sinoaortic denervation markedly reduced baroreflex sensitivity in mid-frequency (-65.6%) and high-frequency (-79.9%) regions (P<0.01), showing the method reflects baroreflex modulation in MF only.