What question did this study set out to answer?

Examining the roles of carotid and aortic baroreceptors in regulating blood pressure and heart rate variability in unanaesthetized cats.

February 1, 1987Journal of Hypertension

Differential Control of Blood Pressure and Heart Rate by Carotid and Aortic Baroreceptors in Unanaesthetized Cats

View Full Paper

Ask AI

Bookmark

Why the study?

Does section of carotid or aortic nerves alter blood pressure and heart rate variability in unanaesthetized cats?

Population

Unanaesthetized, unrestrained cats

Comparison

Section of the carotid sinus or the aortic… vs Intact animals (baseline condition)

Design

Preclinical

Follow-up

1 week after nerve section (measured for 8-10 h)

Authors

GBGiovanni BertinieriOspedale degli Infermi ACAnita CavallazziUniversity of Milan LJLaszlo JaszlitzInternational Drug Development

Discussion

Member takes

Implication

Does not support changes in clinical practice; leaves open translation of differential baroreceptor roles to human variability.

Key Points

Examining the roles of carotid and aortic baroreceptors in regulating blood pressure and heart rate variability in unanaesthetized cats.
Measured blood pressure and heart rate in unrestrained cats over 8-10 hours under three conditions: intact, after carotid/aortic nerve section, and after sino-aortic denervation.
Analyzed signals via computer for mean values and coefficients of variation for blood pressure and heart rate.
Mean blood pressure variability increased significantly after sino-aortic denervation (11.5 ± 1.3%, P < 0.01).
Heart rate variability decreased significantly after either carotid or aortic nerve section, more so after carotid baroreceptor denervation (4.8 ± 0.9%, P < 0.01).
Carotid baroreceptors play a greater role in regulating heart rate variability compared to aortic baroreceptors.

Structured PICO

Does section of carotid or aortic nerves alter blood pressure and heart rate variability in unanaesthetized cats?

Population

Unanaesthetized, unrestrained cats

Intervention

Section of the carotid sinus or the aortic nerves, and sino-aortic denervation (SAD)

Comparator

Intact animals (baseline condition)

Outcome

Blood pressure variability (coefficient of variation for mean blood pressure) and heart rate variability (coefficient of variation for heart rate)surrogate

In unanaesthetized cats, carotid and aortic baroreceptors redundantly control blood pressure variability, but the carotid sinus predominates in controlling heart rate variability.

Cite This Study

Bertinieri et al. (1987) studied this question.

synapsesocial.com/papers/6a77882d576efb0ddaf76bac https://doi.org/10.1097/00004872-198702000-00008

View Full Paper

Ask AI

Bookmark

Differential Control of Blood Pressure and Heart Rate by Carotid and Aortic Baroreceptors in Unanaesthetized Cats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Differential Control of Blood Pressure and Heart Rate by Carotid and Aortic Baroreceptors in Unanaesthetized Cats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider