Key result
Complete sinoaortic denervation greatly increased blood pressure variability compared to baseline (SDs and VLF powers increased ~250%, p<0.01), with aortic and carotid baroreflexes contributing equally.
Population
7 neuromuscular blocked (NMB), Sprague-Dawley, female (225–275 g) rats
Comparison
Aortic denervation and carotid denervation made… vs Baseline (intact baroreflexes)
Design
Preclinical, initial denervation chosen in random order
Follow-up
10 hours
Authors
Loading...
Equal aortic and carotid baroreflex contributions shown in rats; leaves open translation to human BP variability.
p-value: p=<.01
Aortic and carotid baroreflexes contribute equally to the control of blood pressure and heart rate variabilities in a rat model.
Tang et al. (2010) studied Blood pressure variability (n=7). Aortic and carotid denervation vs. Baseline was evaluated on Blood pressure variability (standard deviation and very low frequency power) (p=<.01). Complete sinoaortic denervation greatly increased blood pressure variability compared to baseline (SDs and VLF powers increased ~250%, p<0.01), with aortic and carotid baroreflexes contributing equally.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: