Key result
Mitral annular calcification showed no independent prognostic value for significant coronary atherosclerotic disease after adjusting for confounders (OR 1.60, 95% CI 0.78-3.28, P=0.2).
Why the study?
Evidence on the link between mitral annular calcification and coronary atherosclerotic diseases is lacking, prompting evaluation of its clinical and prognostic value in patients undergoing coronary CT angiography.
Does the presence of mitral annular calcification predict significant coronary atherosclerotic disease in patients undergoing coronary CT angiography?
Cross-Sectional (n=205)
No
Does the presence of mitral annular calcification predict significant coronary atherosclerotic disease in patients undergoing coronary CT angiography?
Odds Ratio: 1.6 (95% CI 0.78–3.28)
Absolute Event Rate: 32.9% vs 20%
p-value: p=0.2
Mitral annular calcification does not have independent prognostic value for significant coronary atherosclerotic disease when assessed by coronary CT angiography after adjusting for confounders.
MAC lacks independent prognostic value on CT angiography; leaves open whether it adds incremental risk information beyond standard factors in prospective cohorts.
Background: There is a lack of evidence on the link between mitral annular calcification (MAC) and coronary atherosclerotic diseases. The present investigation was undertaken to detect the clinical and prognostic value of MAC in coronary atherosclerotic diseases in patients who underwent coronary computed tomographic (CT) angiography. Materials and Methods: Two hundred and five individuals with MAC and without it ( n = 85 and 120, respectively) were included in the present cross-sectional study. Coronary artery disease-reporting and data system (CAD-RADS) at coronary CT angiography was used to define the severity of coronary atherosclerotic diseases. Patients were classified into no or non-significant CAD (CAD-RADS 0–2) and significant CAD (CAD-RADS 3–5) according to the severity of coronary atherosclerotic diseases. The association of MAC with two mentioned groups (no or non-significant CAD and significant CAD) was assessed using the Chi-squared test and logistic regression in crude and adjusted models. Results: Patients with MAC were significantly older (69.34 ± 8.20 vs. 60.64 ± 11.42, P < 0.001), had lower glomerular infiltration rate (69.67 ± 20.92 vs. 78.00 ± 20.23, P = 0.005), and higher coronary artery calcification score (352.87 ± 495.85 vs. 200.55 ± 426.13, P = 0.05) in comparison to those without MAC. However, the significant difference between the two groups regarding coronary artery calcification score disappeared after adjustment for confounders ( P = 0.14). In addition, a statistically significant positive link between MAC and significant CAD was observed (odds ratio [OR] [95% confidence interval (CI)]: 1.96 [1.04–3.71], P = 0.04). Nevertheless, the association became statistically insignificant after adjustment for confounders (OR [95% CI]: 1.60 [0.78–3.28], P = 0.2). Conclusion: The findings of the study revealed that MAC has no independent prognostic value in coronary atherosclerotic diseases evaluated by coronary CT angiography.
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Moradi et al. (2024) conducted a cross-sectional in Coronary atherosclerotic disease (n=205). Mitral annular calcification vs. No mitral annular calcification was evaluated on Significant coronary artery disease (CAD-RADS 3-5) (OR 1.60, 95% CI 0.78-3.28, p=0.2). Mitral annular calcification showed no independent prognostic value for significant coronary atherosclerotic disease after adjusting for confounders (OR 1.60, 95% CI 0.78-3.28, P=0.2).
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