Key result
Elevated depressive symptoms at baseline were associated with a significantly increased risk of hospitalization with acute kidney injury (HR 1.53) independent of traditional renal disease risk factors.
Why the study?
Do depressive symptoms increase the risk of rapid kidney function decline and adverse clinical renal disease outcomes in individuals not yet on dialysis?
Cohort (n=5,785)
Yes
Do depressive symptoms increase the risk of rapid kidney function decline and adverse clinical renal disease outcomes in individuals not yet on dialysis?
Hazard Ratio: 1.53 (95% CI 1.11–2.1)
Absolute Event Rate: 5% vs 3.7%
p-value: p=<0.05
Elevated depressive symptoms are independently associated with a higher risk of hospitalization for acute kidney injury in individuals not yet on dialysis.
No takes yet. Share an insight, caveat, or question.
Depressive symptoms may flag higher AKI risk in pre-dialysis CKD; hypothesis-generating and should not yet change practice.
Kop et al. (2011) conducted a cohort in Chronic Kidney Disease Risk (n=5,785). Elevated depressive symptoms (CES-D ≥ 8) vs. Low depressive symptoms (CES-D < 8) was evaluated on Hospitalization with acute kidney injury (AKI) (HR 1.53, 95% CI 1.11-2.10, p=<0.05). Elevated depressive symptoms at baseline were associated with a significantly increased risk of hospitalization with acute kidney injury (HR 1.53) independent of traditional renal disease risk factors.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: