Lithium, at a dosage of 1,800 mg. daily, was found to be effective in the treatment of acute manic states. However, when compared with chlorpromazine by means of a double-blind technique using stringent diagnostic criteria, no significant difference between the two drugs was noted. In regard to the prophylactic effect of lithium, the data presented indicate that this question is still unresolved.
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Spring et al. (1970) studied this question.
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