Key result
Doxorubicin and Herceptin significantly disrupted tight junction formation and increased permeability in human cardiac microvascular endothelial cells compared to vehicle control.
Why the study?
Do trastuzumab and doxorubicin disrupt tight junction barrier formation in human cardiac microvascular endothelial cells?
Population
Human cardiac microvascular endothelial cells, human dermal microvascular endothelial cells, and human brain…
Comparison
Trastuzumab (Herceptin) and doxorubicin vs Untreated cells / comparison across different…
Design
Preclinical
Authors
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May suggest endothelial permeability mechanism in cardiotoxicity; hypothesis-generating and should not change practice.
Do trastuzumab and doxorubicin disrupt tight junction barrier formation in human cardiac microvascular endothelial cells?
Trastuzumab and doxorubicin disrupt tight junctions in cardiac microvascular endothelial cells, suggesting a novel mechanism for their cardiotoxicity via increased drug permeability to cardiomyocytes.
Wilkinson et al. (2016) studied Cardiotoxicity. Herceptin and doxorubicin vs. Vehicle control was evaluated on Endothelial cell permeability and tight junction barrier formation. Doxorubicin and Herceptin significantly disrupted tight junction formation and increased permeability in human cardiac microvascular endothelial cells compared to vehicle control.
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