Key result
Enhanced recovery after surgery protocols and opioid-free analgesics provide effective postoperative pain management while minimizing the adverse effects and addiction risks associated with exogenous opioids.
Why the study?
Opioids impair endogenous beta-endorphin function and cause adverse effects that impede recovery, prompting the exploration of nonopioid modalities and non-narcotic enhanced recovery after surgery protocols.
Answers are grounded in this paper and cite their sources.
Opioid-free analgesia and enhanced recovery after surgery (ERAS) protocols offer effective alternatives to traditional opioid-based regimens for postoperative pain management, potentially reducing opioid-related adverse effects and improving patient recovery.
Opioid medications are commonly employed for perioperative and postoperative pain management. However, these medications can negatively impact the body's innate pain management system, specifically the action of beta-endorphins. By impairing the function of mu-opioid receptors and inhibiting the release of beta-endorphin, opioids may exacerbate and prolong postoperative pain. Additionally, opioid use is associated with numerous side effects, including nausea, vomiting, constipation, excessive sedation, clouded sensorium, dizziness, respiratory depression, and addiction, all of which may impede postoperative patient recovery and outcome quality. The purpose of this article is to explore the intricate relationship between opioid medications and endogenous beta-endorphins, examine nonopioid modalities for postoperative pain control, and elucidate the applications of non-narcotic perioperative enhanced recovery after surgery protocols in improving patient outcomes.
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Na et al. (2024) conducted a review in Postoperative pain. Opioid-free analgesics and Enhanced Recovery After Surgery (ERAS) protocols vs. Opioid-based regimens was evaluated. Enhanced recovery after surgery protocols and opioid-free analgesics provide effective postoperative pain management while minimizing the adverse effects and addiction risks associated with exogenous opioids.
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