In a mouse model, chronic coxsackie-virus B1 infection is associated with elevated IL-6 transcription in the brain, which normalizes upon viral clearance.
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IL-6 normalization upon clearance may mark viral resolution in mouse brain; leaves open relevance to human chronic enteroviral disease.
An animal model of chronic enteroviral infection was established by using PCR to detect viral genomes in animal tissues and to compare levels of transcription of a variety of cytokines in the brain. Chronic coxsackie-virus B1 infection was found in both brain and skeletal muscle of mice infected as neonates. The viral infection cleared by 240 days post-infection. Elevated levels of tumour necrosis factor alpha and interleukin-6 (IL-6) would appear to be linked to acute and chronic infection respectively. Levels of IL-6 return to normal upon clearance of the virus.
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Cavanagh et al. (1993) studied this question.
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