December 2, 1995European Heart Journal
Enterovirus-infected immune cells of spleen and lymph nodes in the murine model of chronic myocarditis: a role in pathogenesis?
Population
Immunocompetent mice infected with group B coxsackieviruses (CVB3) as a model of chronic myocarditis
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May indicate lymphoid reservoirs in chronic myocarditis models; hypothesis-generating and requires human validation before clinical relevance.
Structured PICO
P
Population
Immunocompetent mice infected with group B coxsackieviruses (CVB3) as a model of chronic myocarditis
I
Intervention
In-situ hybridization to detect enterovirus
O
Outcome
Presence and localization of enterovirus infection in spleen and lymph nodessurrogate
Enterovirus persistence in the spleen and lymph nodes of mice suggests that infected immunocompetent cells may maintain a non-cardiac viral reservoir in chronic myocarditis.
Cite This Study
Klingel et al. (1995) studied this question.