Caveolins play a crucial role in organizing and modulating vascular smooth muscle function, with implications for cardiovascular abnormalities.
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May guide preclinical vascular research; leaves open therapeutic relevance in human disease.
Caveolae are becoming increasingly recognized as an important organizational structure for a variety of signal and energy-transducing systems in vascular smooth muscle (VSM). In this review, we discuss the emerging role of the caveolins in organizing and modulating the basic functions of smooth muscle: contraction, growth/proliferation, and the energetic support systems that support these functions. With clear alterations in cell metabolism and function in VSM with altered caveolin-1 (Cav-1) protein expression and with cardiovascular abnormalities associated with Cav-1 null mice, the caveolin family of proteins may play an important role in the function and dysfunction of VSM.
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Hardin et al. (2006) studied this question.
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