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March 1, 2001HeartOpen Access

Aspirin for primary prevention of coronary heart disease: safety and absolute benefit related to coronary risk derived from meta-analysis of randomised trials

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Why the study?

Does aspirin reduce cardiovascular events and myocardial infarctions in primary prevention populations?

Population

Meta-analysis of four randomised controlled trials of aspirin for primary prevention of coronary heart disease

Design

Meta-analysis

Authors

PSP. S SanmuganathanCliniques Universitaires Saint-Luc

Discussion

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Implication

Supports aspirin in primary prevention only at coronary risk ≥1.5%/year; challenges routine use at lower risks where bleeding predominates.

Structured PICO

Does aspirin reduce cardiovascular events and myocardial infarctions in primary prevention populations?

P
Population
Meta-analysis of four randomised controlled trials of aspirin for primary prevention of coronary heart disease
I
Intervention
Aspirin
O
Outcome
Benefit from aspirin, expressed as reduction in cardiovascular events, myocardial infarctions, strokes, and total mortality; harm caused by aspirin in relation to significant bleeds and major haemorrhageshard clinical

Aspirin for primary prevention provides a net benefit at a coronary event risk of ≥1.5%/year, but the risk of bleeding outweighs benefits at a risk of 0.5%/year.

Cite This Study

P. S Sanmuganathan (2001) studied this question.

synapsesocial.com/papers/6a7ca04ae7df423ee14c74c0https://doi.org/10.1136/heart.85.3.265

Topics

Cardiovascular preventionDual antiplatelet therapyWomen and heart disease
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Also Consider

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