Why the study?
Does prophylactic aspirin at doses of 300 mg daily or less increase the risk of hospitalisation for bleeding peptic ulcer?
Population
1121 patients with gastric or duodenal ulcer bleeding matched with hospital and community controls
Comparison
Prophylactic aspirin regimens of 300 mg daily or… vs Hospital and community controls without gastric…
Design
Case-control
Authors
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Low-dose aspirin associated with dose-dependent bleeding risk; supports caution in prophylaxis but leaves optimal use open pending RCTs.
Does prophylactic aspirin at doses of 300 mg daily or less increase the risk of hospitalisation for bleeding peptic ulcer?
Prophylactic aspirin at doses of 75-300 mg daily is associated with a dose-dependent increased risk of hospitalization for bleeding peptic ulcer.
Weil et al. (1995) studied this question.
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