What is the clinical evidence from this study?

Population: Chikungunya virus (CHIKV) infection. Intervention: Favipiravir (T-705). Primary outcome: Antiviral effect on CHIKV replication and identification of resistance mutations.

June 20, 2014Journal of Antimicrobial ChemotherapyOpen Access

Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral

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Key result

Favipiravir inhibits chikungunya virus replication, and resistance is driven by a unique K291R mutation in the RNA-dependent RNA polymerase.

Why the study?

Does favipiravir inhibit chikungunya virus replication and what is the mechanism of resistance?

Population

Cell culture and a mouse model of lethal chikungunya virus (CHIKV) infection

Design

Preclinical

Authors

LDLeen DelangRega Institute for Medical Research NGNidya Alexandra Segura GuerreroPedagogical and Technological University of Colombia ATAli TaşLeiden University Medical Center

Discussion

Member takes

Implication

Hypothesis-generating for favipiravir against chikungunya; human trials needed before clinical consideration.

Structured PICO

Does favipiravir inhibit chikungunya virus replication and what is the mechanism of resistance?

Population

Cell culture and a mouse model of lethal chikungunya virus (CHIKV) infection

Intervention

Favipiravir (T-705)

Outcome

Antiviral effect on CHIKV replication and identification of resistance mutationssurrogate

Favipiravir inhibits chikungunya virus replication, and resistance is mediated by a specific K291R mutation in the viral RNA-dependent RNA polymerase.

Cite This Study

Delang et al. (2014) studied Chikungunya virus (CHIKV) infection. Favipiravir (T-705) was evaluated on Antiviral effect on CHIKV replication and identification of resistance mutations. Favipiravir inhibits chikungunya virus replication, and resistance is driven by a unique K291R mutation in the RNA-dependent RNA polymerase.

synapsesocial.com/papers/6a7ca0f5f108d7d7faba495c https://doi.org/10.1093/jac/dku209

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Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider